Inhaled microparticles containing clofazimine are efficacious in treatment of experimental tuberculosis in mice.
نویسندگان
چکیده
Inhalable clofazimine-containing dry powder microparticles (CFM-DPI) and native clofazimine (CFM) were evaluated for activity against Mycobacterium tuberculosis in human monocyte-derived macrophage cultures and in mice infected with a low-dose aerosol. Both formulations resulted in 99% killing at 2.5 μg/ml in vitro. In mice, 480 μg and 720 μg CFM-DPI inhaled twice per week over 4 weeks reduced numbers of CFU in the lung by as much as log(10) 2.6; 500 μg oral CFM achieved a log(10) 0.7 reduction.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 57 2 شماره
صفحات -
تاریخ انتشار 2013